Proprietary blend: Glycine
Glycine is a protein amino acid found in the protein of all life forms. It is the simplest amino
acid in the body. Although most glycine is found in proteins, free glycine is found in body
fluids as well as in plants. The normal diet contributes approximately 2 grams of glycine
daily.

Glycine is of major importance in the synthesis of proteins, peptides, purines, adenosine
triphosphate (ATP), nucleic acids, porphyrins, hemoglobin, glutathione, creatine, bile salts,
one-carbon fragments, glucose, glycogen, and L-serine and other amino acids. Glycine is
also a neurotransmitter in the central nervous system (CNS). Glycine and
gamma-aminobutyric acid (GABA) are the major inhibitory neurotransmitters in the CNS.
Recently, a glycine-gated chloride channel has been identified in neurophils that can
attenuate increases in intracellular calcium ions and diminish oxidant damage mediated
by these white blood cells. Thus, glycine may be a novel antioxidant.

High-dose glycine may be beneficial in the management of enduring negative symptoms
of schizophrenia. Twenty-two treatment-resistant schizophrenic patients participated in a
double-blind, placebo-controlled, six-week, crossover treatment trial with 0.8 grams per
kilogram daily of glycine added to their ongoing antipsychotic medication. Glycine intake
ranged from 40 to 90 grams daily. Only mild gastrointestinal side effects (nausea and
vomiting) were reported in one patient taking glycine. Patients taking glycine experienced
significantly diminished negative symptoms.

Recent animal studies suggest that glycine may have some anti-cancer properties. In one
recent study, 51 weeks of glycine supplementation did not stop early foci formation of
cancer but reduced formation of small liver tumors by 23%, medium-sized tumors by 64%
and large tumors by nearly 80% in rats given an agent that is a peroxisome proliferator and
liver carcinogen.

In another recent study, dietary glycine inhibited B16 melanoma tumors in mice.
Glycine-supplemented mice had tumors that were 50 to 70% smaller in size than those in
controls. The protective mechanism in this case appeared to be inhibition of angiogenesis
effected by suppressed endothelial-cell proliferation. Tumors in mice fed glycine had 70%
fewer arteries than were present in the tumors of controls.

REFERENCES
1. de Kooning JT, Duran M, Dorling L, et al. Beneficial effects of L-serine and glycine in the
management of seizures in 3-phosphoglycerate dehydrogenase deficiency. Ann Neurol.
1998; 44:261-265.
2. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment
of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry. 1999; 56:29-36.
3. Rose ML, Cattley RC, Dunn C, et al. Dietary glycine prevents the development of liver
tumors caused by the peroxisome proliferator WY-14, 643. Carcinogenesis. 1999;
20:2075-2081.
4.Rose ML, Madren J, Bunzendahl H, Thurman RG. Dietary glycine inhibits the growth of
B16 melanoma tumors in mice. Carcinogenesis. 1999; 20:793-798
Price: $ 20.00

Count:
120 Capsules
Serving Per Bottle:
Approx. 25 Servings
Net Weight:
750 mg.
Suggested Usage:
As a dietary supplement, take  
2 or 3 capsules two times a day.
Glycine
Information*
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
**The information provided on this site is for informational purposes only, not intended to replace your doctor's or other health care professional's advice
or treatment. Nor is any information contained on or in any product label or packaging intended to provide or replace professional health care advice. Do
not use the this site's information for diagnosis or treatment of any health problem, nor for prescription of any treatment or medication. Always consult with
a healthcare professional before undertaking any diet, exercise, herbal or other supplementation program, taking any medications, or if you suspect you
may have or already have any type of health problem. Do not stop taking any medication without first consulting your doctor.
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